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レポート概要
| 新型コロナウイルス感染症とロシア・ウクライナ戦争の影響により、エスケタミン塩酸塩のグローバル市場は 2022にxxxドルと推定され、2028年までにxxxドルの規模に達し、2022年から2028年の予測期間中にxxx%のCAGRで成長すると予測されています。 エスケタミン塩酸塩のアメリカ市場は、2023年から2028年の予測期間中にxxx%のCAGRで、2022年xxxドルから2028年xxxドルに達すると推定されています。 エスケタミン塩酸塩の中国市場は、2023年から2028年の予測期間中にxxx%のCAGRで、2022年xxxドルから2028年xxxドルに達すると推定されています。 エスケタミン塩酸塩のヨーロッパ市場は、2023年から2028年の予測期間中にxxx%のCAGRで、2022年xxxドルから2028年xxxドルに達すると推定されています。 生産面において、本レポートは2017年から2022年までのエスケタミン塩酸塩の生産、成長率、メーカー別市場シェア、地域別市場シェア、および2028年までの予測を調査しています。販売面において、本レポートは2017年から2022年までの地域別、企業別、タイプ別、アプリケーション別のエスケタミン塩酸塩の売上および2028年までの予測に焦点を当てています。 エスケタミン塩酸塩のグローバル主要企業には、Yangtze River Pharmaceutical、Sinopharm、Humanwell Pharmaceutical、Hengrui、JNJ、Pfizerなどがあります。2021年、世界のトップ5プレイヤーは売上ベースで約xxx％の市場シェアを占めています。 エスケタミン塩酸塩市場は、タイプとアプリケーションによって区分されます。世界のエスケタミン塩酸塩市場のプレーヤー、利害関係者、およびその他の参加者は、当レポートを有益なリソースとして使用することで優位に立つことができます。セグメント分析は、2017年～2028年期間のタイプ別およびアプリケーション別の販売量、売上、予測に焦点を当てています。 【タイプ別セグメント】 5Kg、3Kg、1Kg、その他 【アプリケーション別セグメント】 薬局、病院 【掲載地域】 北米：アメリカ、カナダ ヨーロッパ：ドイツ、フランス、イギリス、イタリア、ロシア アジア太平洋：日本、中国、韓国、インド、オーストラリア、台湾、インドネシア、タイ、マレーシア 中南米：メキシコ、ブラジル、アルゼンチン 中東・アフリカ：トルコ、サウジアラビア、UAE 【目次（一部）】 ・調査の範囲 - エスケタミン塩酸塩製品概要 - タイプ別市場（5Kg、3Kg、1Kg、その他） - アプリケーション別市場（薬局、病院） - 調査の目的 ・エグゼクティブサマリー - 世界のエスケタミン塩酸塩販売量予測2017-2028 - 世界のエスケタミン塩酸塩売上予測2017-2028 - エスケタミン塩酸塩の地域別販売量 - エスケタミン塩酸塩の地域別売上 - 北米市場 - ヨーロッパ市場 - アジア太平洋市場 - 中南米市場 - 中東・アフリカ市場 ・メーカーの競争状況 - 主要メーカー別エスケタミン塩酸塩販売量 - 主要メーカー別エスケタミン塩酸塩売上 - 主要メーカー別エスケタミン塩酸塩価格 - 競争状況の分析 - 企業M&A動向 ・タイプ別市場規模（5Kg、3Kg、1Kg、その他） - エスケタミン塩酸塩のタイプ別販売量 - エスケタミン塩酸塩のタイプ別売上 - エスケタミン塩酸塩のタイプ別価格 ・アプリケーション別市場規模（薬局、病院） - エスケタミン塩酸塩のアプリケーション別販売量 - エスケタミン塩酸塩のアプリケーション別売上 - エスケタミン塩酸塩のアプリケーション別価格 ・北米市場 - 北米のエスケタミン塩酸塩市場規模（タイプ別、アプリケーション別） - 主要国別のエスケタミン塩酸塩市場規模（アメリカ、カナダ） ・ヨーロッパ市場 - ヨーロッパのエスケタミン塩酸塩市場規模（タイプ別、アプリケーション別） - 主要国別のエスケタミン塩酸塩市場規模（ドイツ、フランス、イギリス、イタリア、ロシア） ・アジア太平洋市場 - アジア太平洋のエスケタミン塩酸塩市場規模（タイプ別、アプリケーション別） - 主要国別のエスケタミン塩酸塩市場規模（日本、中国、韓国、インド、オーストラリア、台湾、インドネシア、タイ、マレーシア） ・中南米市場 - 中南米のエスケタミン塩酸塩市場規模（タイプ別、アプリケーション別） - 主要国別のエスケタミン塩酸塩市場規模（メキシコ、ブラジル、アルゼンチン） ・中東・アフリカ市場 - 中東・アフリカのエスケタミン塩酸塩市場規模（タイプ別、アプリケーション別） - 主要国別のエスケタミン塩酸塩市場規模（トルコ、サウジアラビア） ・企業情報 Yangtze River Pharmaceutical、Sinopharm、Humanwell Pharmaceutical、Hengrui、JNJ、Pfizer ・産業チェーン及び販売チャネル分析 - エスケタミン塩酸塩の産業チェーン分析 - エスケタミン塩酸塩の原材料 - エスケタミン塩酸塩の生産プロセス - エスケタミン塩酸塩の販売及びマーケティング - エスケタミン塩酸塩の主要顧客 ・マーケットドライバー、機会、課題、リスク要因分析 - エスケタミン塩酸塩の産業動向 - エスケタミン塩酸塩のマーケットドライバー - エスケタミン塩酸塩の課題 - エスケタミン塩酸塩の阻害要因 ・主な調査結果 |
Report Overview
Due to the COVID-19 pandemic and Russia-Ukraine War Influence, the global market for Product Name estimated at US$ million in the year 2022, is projected to reach a revised size of US$ million by 2028, growing at a CAGR of % during the forecast period 2022-2028.
Drugs for the treatment of depression disorders
Report Scope
This latest report researches the industry structure, sales, revenue, price and gross margin. Major producers’ production locations, market shares, industry ranking and profiles are presented. The primary and secondary research is done in order to access up-to-date government regulations, market information and industry data. Data were collected from the Esketamine Hydrochloride manufacturers, distributors, end users, industry associations, governments’ industry bureaus, industry publications, industry experts, third party database, and our in-house databases.
This report also includes a discussion of the major players across each regional Esketamine Hydrochloride market. Further, it explains the major drivers and regional dynamics of the global Esketamine Hydrochloride market and current trends within the industry.
Key Companies Covered
In this section of the report, the researchers have done a comprehensive analysis of the prominent players operating and the strategies they are focusing on to combat the intense competition. Company profiles and market share analysis of the prominent players are also provided in this section. Additionally, the specialists have done an all-encompassing analysis of each player. They have also provided reliable sales, revenue, price, market share and rank data of the manufacturers for the period 2017-2022. With the assistance of this report, key players, stakeholders, and other participants will be able to stay abreast of the recent and upcoming developments in the business, further enabling them to make efficient choices. Mentioned below are the prime players taken into account in this research report:
Yangtze River Pharmaceutical
Sinopharm
Humanwell Pharmaceutical
Hengrui
JNJ
Pfizer
Market Segments
This report has explored the key segments: by Type and by Application. The lucrativeness and growth potential have been looked into by the industry experts in this report. This report also provides sales, revenue and average price forecast data by specification and by application segments based on sales, price, and value for the period 2017-2028.
Esketamine Hydrochloride Segment by Specification
5Kg
3Kg
1Kg
Other
Esketamine Hydrochloride Segment by Application
Pharmacy
Hospital
Key Regions & Countries
This section of the report provides key insights regarding various regions and the key players operating in each region. Economic, social, environmental, technological, and political factors have been taken into consideration while assessing the growth of the particular region/country. The readers will also get their hands on the value and sales data of each region and country for the period 2017-2028.
North America
United States
Canada
Europe
Germany
France
U.K.
Italy
Russia
Asia-Pacific
China
Japan
South Korea
India
Australia
China Taiwan
Indonesia
Thailand
Malaysia
Latin America
Mexico
Brazil
Argentina
Middle East & Africa
Turkey
Saudi Arabia
UAE
Key Drivers & Barriers
High-impact rendering factors and drivers have been studied in this report to aid the readers to understand the general development. Moreover, the report includes restraints and challenges that may act as stumbling blocks on the way of the players. This will assist the users to be attentive and make informed decisions related to business. Specialists have also laid their focus on the upcoming business prospects.
COVID-19 and Russia-Ukraine War Influence Analysis
The readers in the section will understand how the Esketamine Hydrochloride market scenario changed across the globe during the pandemic, post-pandemic and Russia-Ukraine War. The study is done keeping in view the changes in aspects such as demand, consumption, transportation, consumer behavior, supply chain management, export and import, and production. The industry experts have also highlighted the key factors that will help create opportunities for players and stabilize the overall industry in the years to come.
Report Includes:
This report presents an overview of global market for Esketamine Hydrochloride, sales, revenue and price. Analyses of the global market trends, with historic market revenue/sales data for 2017 – 2021, estimates for 2022, and projections of CAGR through 2028.
This report researches the key producers of Esketamine Hydrochloride, also provides the sales of main regions and countries. Highlights of the upcoming market potential for Esketamine Hydrochloride, and key regions/countries of focus to forecast this market into various segments and sub-segments. Country specific data and market value analysis for the U.S., Canada, Mexico, Brazil, China, Japan, South Korea, Southeast Asia, India, Germany, the U.K., Italy, Middle East, Africa, and Other Countries.
This report focuses on the Esketamine Hydrochloride sales, revenue, market share and industry ranking of main manufacturers, data from 2017 to 2022. Identification of the major stakeholders in the global Esketamine Hydrochloride market, and analysis of their competitive landscape and market positioning based on recent developments and segmental revenues. This report will help stakeholders to understand the competitive landscape and gain more insights and position their businesses and market strategies in a better way.
This report analyzes the segments data by type and by application, sales, revenue, and price, from 2017 to 2028. Evaluation and forecast the market size for Esketamine Hydrochloride sales, projected growth trends, production technology, application and end-user industry.
Descriptive company profiles of the major global players, including Yangtze River Pharmaceutical, Sinopharm, Humanwell Pharmaceutical, Hengrui, JNJ and Pfizer, etc.
Chapter Outline
Chapter 1: Introduces the report scope of the report, executive summary of different market segments (product type, application, etc), including the market size of each market segment, future development potential, and so on. It offers a high-level view of the current state of the market and its likely evolution in the short to mid-term, and long term.
Chapter 2: Sales (consumption), revenue of Esketamine Hydrochloride in global, regional level and country level. It provides a quantitative analysis of the market size and development potential of each region and its main countries and introduces the market development, future development prospects, market space, and capacity of each country in the world.
Chapter 3: Detailed analysis of Esketamine Hydrochloride manufacturers competitive landscape, price, sales, revenue, market share and industry ranking, latest development plan, merger, and acquisition information, etc.
Chapter 4: Provides the analysis of various market segments according to product types, covering the sales, revenue, average price, and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter 5: Provides the analysis of various market segments according to application, covering the sales, revenue, average price, and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter 6: North America by specification, by application and by country, sales and revenue for each segment.
Chapter 7: Europe by specification, by application and by country, sales and revenue for each segment.
Chapter 8: Asia Pacific by specification, by application and by country, sales and revenue for each segment.
Chapter 9: Latin America by specification, by application and by country, sales and revenue for each segment.
Chapter 10: Middle East and Africa by specification, by application and by country, sales and revenue for each segment.
Chapter 11: Provides profiles of key manufacturers, introducing the basic situation of the main companies in the market in detail, including product descriptions and specifications, Esketamine Hydrochloride sales, revenue, price, gross margin, and recent development, etc.
Chapter 12: Analysis of industrial chain, sales channel, key raw materials, distributors and customers.
Chapter 13: Introduces the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.
Chapter 14: The main points and conclusions of the report.
1 Study Coverage
1.1 Esketamine Hydrochloride Product Introduction
1.2 Market by Specification
1.2.1 Global Esketamine Hydrochloride Market Size Growth Rate by Specification, 2017 VS 2021 VS 2028
1.2.2 5Kg
1.2.3 3Kg
1.2.4 1Kg
1.2.5 Other
1.3 Market by Application
1.3.1 Global Esketamine Hydrochloride Market Size Growth Rate by Application, 2017 VS 2021 VS 2028
1.3.2 Pharmacy
1.3.3 Hospital
1.4 Study Objectives
1.5 Years Considered
2 Executive Summary
2.1 Global Esketamine Hydrochloride Sales Estimates and Forecasts 2017-2028
2.2 Global Esketamine Hydrochloride Revenue Estimates and Forecasts 2017-2028
2.3 Global Esketamine Hydrochloride Revenue by Region: 2017 VS 2021 VS 2028
2.4 Global Esketamine Hydrochloride Sales by Region
2.4.1 Global Esketamine Hydrochloride Sales by Region (2017-2022)
2.4.2 Global Sales Esketamine Hydrochloride by Region (2023-2028)
2.5 Global Esketamine Hydrochloride Revenue by Region
2.5.1 Global Esketamine Hydrochloride Revenue by Region (2017-2022)
2.5.2 Global Esketamine Hydrochloride Revenue by Region (2023-2028)
2.6 North America
2.7 Europe
2.8 Asia-Pacific
2.9 Latin America
2.10 Middle East & Africa
3 Competition by Manufacturers
3.1 Global Esketamine Hydrochloride Sales by Manufacturers
3.1.1 Global Top Esketamine Hydrochloride Manufacturers by Sales (2017-2022)
3.1.2 Global Esketamine Hydrochloride Sales Market Share by Manufacturers (2017-2022)
3.1.3 Global Top 10 and Top 5 Largest Manufacturers of Esketamine Hydrochloride in 2021
3.2 Global Esketamine Hydrochloride Revenue by Manufacturers
3.2.1 Global Esketamine Hydrochloride Revenue by Manufacturers (2017-2022)
3.2.2 Global Esketamine Hydrochloride Revenue Market Share by Manufacturers (2017-2022)
3.2.3 Global Top 10 and Top 5 Companies by Esketamine Hydrochloride Revenue in 2021
3.3 Global Esketamine Hydrochloride Sales Price by Manufacturers (2017-2022)
3.4 Analysis of Competitive Landscape
3.4.1 Manufacturers Market Concentration Ratio (CR5 and HHI)
3.4.2 Global Esketamine Hydrochloride Market Share by Company Type (Tier 1, Tier 2, and Tier 3)
3.4.3 Global Esketamine Hydrochloride Manufacturers Geographical Distribution
3.5 Mergers & Acquisitions, Expansion Plans
4 Market Size by Specification
4.1 Global Esketamine Hydrochloride Sales by Specification
4.1.1 Global Esketamine Hydrochloride Historical Sales by Specification (2017-2022)
4.1.2 Global Esketamine Hydrochloride Forecasted Sales by Specification (2023-2028)
4.1.3 Global Esketamine Hydrochloride Sales Market Share by Specification (2017-2028)
4.2 Global Esketamine Hydrochloride Revenue by Specification
4.2.1 Global Esketamine Hydrochloride Historical Revenue by Specification (2017-2022)
4.2.2 Global Esketamine Hydrochloride Forecasted Revenue by Specification (2023-2028)
4.2.3 Global Esketamine Hydrochloride Revenue Market Share by Specification (2017-2028)
4.3 Global Esketamine Hydrochloride Price by Specification
4.3.1 Global Esketamine Hydrochloride Price by Specification (2017-2022)
4.3.2 Global Esketamine Hydrochloride Price Forecast by Specification (2023-2028)
5 Market Size by Application
5.1 Global Esketamine Hydrochloride Sales by Application
5.1.1 Global Esketamine Hydrochloride Historical Sales by Application (2017-2022)
5.1.2 Global Esketamine Hydrochloride Forecasted Sales by Application (2023-2028)
5.1.3 Global Esketamine Hydrochloride Sales Market Share by Application (2017-2028)
5.2 Global Esketamine Hydrochloride Revenue by Application
5.2.1 Global Esketamine Hydrochloride Historical Revenue by Application (2017-2022)
5.2.2 Global Esketamine Hydrochloride Forecasted Revenue by Application (2023-2028)
5.2.3 Global Esketamine Hydrochloride Revenue Market Share by Application (2017-2028)
5.3 Global Esketamine Hydrochloride Price by Application
5.3.1 Global Esketamine Hydrochloride Price by Application (2017-2022)
5.3.2 Global Esketamine Hydrochloride Price Forecast by Application (2023-2028)
6 North America
6.1 North America Esketamine Hydrochloride Market Size by Specification
6.1.1 North America Esketamine Hydrochloride Sales by Specification (2017-2028)
6.1.2 North America Esketamine Hydrochloride Revenue by Specification (2017-2028)
6.2 North America Esketamine Hydrochloride Market Size by Application
6.2.1 North America Esketamine Hydrochloride Sales by Application (2017-2028)
6.2.2 North America Esketamine Hydrochloride Revenue by Application (2017-2028)
6.3 North America Esketamine Hydrochloride Market Size by Country
6.3.1 North America Esketamine Hydrochloride Sales by Country (2017-2028)
6.3.2 North America Esketamine Hydrochloride Revenue by Country (2017-2028)
6.3.3 United States
6.3.4 Canada
7 Europe
7.1 Europe Esketamine Hydrochloride Market Size by Specification
7.1.1 Europe Esketamine Hydrochloride Sales by Specification (2017-2028)
7.1.2 Europe Esketamine Hydrochloride Revenue by Specification (2017-2028)
7.2 Europe Esketamine Hydrochloride Market Size by Application
7.2.1 Europe Esketamine Hydrochloride Sales by Application (2017-2028)
7.2.2 Europe Esketamine Hydrochloride Revenue by Application (2017-2028)
7.3 Europe Esketamine Hydrochloride Market Size by Country
7.3.1 Europe Esketamine Hydrochloride Sales by Country (2017-2028)
7.3.2 Europe Esketamine Hydrochloride Revenue by Country (2017-2028)
7.3.3 Germany
7.3.4 France
7.3.5 U.K.
7.3.6 Italy
7.3.7 Russia
8 Asia Pacific
8.1 Asia Pacific Esketamine Hydrochloride Market Size by Specification
8.1.1 Asia Pacific Esketamine Hydrochloride Sales by Specification (2017-2028)
8.1.2 Asia Pacific Esketamine Hydrochloride Revenue by Specification (2017-2028)
8.2 Asia Pacific Esketamine Hydrochloride Market Size by Application
8.2.1 Asia Pacific Esketamine Hydrochloride Sales by Application (2017-2028)
8.2.2 Asia Pacific Esketamine Hydrochloride Revenue by Application (2017-2028)
8.3 Asia Pacific Esketamine Hydrochloride Market Size by Region
8.3.1 Asia Pacific Esketamine Hydrochloride Sales by Region (2017-2028)
8.3.2 Asia Pacific Esketamine Hydrochloride Revenue by Region (2017-2028)
8.3.3 China
8.3.4 Japan
8.3.5 South Korea
8.3.6 India
8.3.7 Australia
8.3.8 China Taiwan
8.3.9 Indonesia
8.3.10 Thailand
8.3.11 Malaysia
9 Latin America
9.1 Latin America Esketamine Hydrochloride Market Size by Specification
9.1.1 Latin America Esketamine Hydrochloride Sales by Specification (2017-2028)
9.1.2 Latin America Esketamine Hydrochloride Revenue by Specification (2017-2028)
9.2 Latin America Esketamine Hydrochloride Market Size by Application
9.2.1 Latin America Esketamine Hydrochloride Sales by Application (2017-2028)
9.2.2 Latin America Esketamine Hydrochloride Revenue by Application (2017-2028)
9.3 Latin America Esketamine Hydrochloride Market Size by Country
9.3.1 Latin America Esketamine Hydrochloride Sales by Country (2017-2028)
9.3.2 Latin America Esketamine Hydrochloride Revenue by Country (2017-2028)
9.3.3 Mexico
9.3.4 Brazil
9.3.5 Argentina
10 Middle East and Africa
10.1 Middle East and Africa Esketamine Hydrochloride Market Size by Specification
10.1.1 Middle East and Africa Esketamine Hydrochloride Sales by Specification (2017-2028)
10.1.2 Middle East and Africa Esketamine Hydrochloride Revenue by Specification (2017-2028)
10.2 Middle East and Africa Esketamine Hydrochloride Market Size by Application
10.2.1 Middle East and Africa Esketamine Hydrochloride Sales by Application (2017-2028)
10.2.2 Middle East and Africa Esketamine Hydrochloride Revenue by Application (2017-2028)
10.3 Middle East and Africa Esketamine Hydrochloride Market Size by Country
10.3.1 Middle East and Africa Esketamine Hydrochloride Sales by Country (2017-2028)
10.3.2 Middle East and Africa Esketamine Hydrochloride Revenue by Country (2017-2028)
10.3.3 Turkey
10.3.4 Saudi Arabia
11 Company Profiles
11.1 Yangtze River Pharmaceutical
11.1.1 Yangtze River Pharmaceutical Corporation Information
11.1.2 Yangtze River Pharmaceutical Overview
11.1.3 Yangtze River Pharmaceutical Esketamine Hydrochloride Sales, Price, Revenue and Gross Margin (2017-2022)
11.1.4 Yangtze River Pharmaceutical Esketamine Hydrochloride Product Model Numbers, Pictures, Descriptions and Specifications
11.1.5 Yangtze River Pharmaceutical Recent Developments
11.2 Sinopharm
11.2.1 Sinopharm Corporation Information
11.2.2 Sinopharm Overview
11.2.3 Sinopharm Esketamine Hydrochloride Sales, Price, Revenue and Gross Margin (2017-2022)
11.2.4 Sinopharm Esketamine Hydrochloride Product Model Numbers, Pictures, Descriptions and Specifications
11.2.5 Sinopharm Recent Developments
11.3 Humanwell Pharmaceutical
11.3.1 Humanwell Pharmaceutical Corporation Information
11.3.2 Humanwell Pharmaceutical Overview
11.3.3 Humanwell Pharmaceutical Esketamine Hydrochloride Sales, Price, Revenue and Gross Margin (2017-2022)
11.3.4 Humanwell Pharmaceutical Esketamine Hydrochloride Product Model Numbers, Pictures, Descriptions and Specifications
11.3.5 Humanwell Pharmaceutical Recent Developments
11.4 Hengrui
11.4.1 Hengrui Corporation Information
11.4.2 Hengrui Overview
11.4.3 Hengrui Esketamine Hydrochloride Sales, Price, Revenue and Gross Margin (2017-2022)
11.4.4 Hengrui Esketamine Hydrochloride Product Model Numbers, Pictures, Descriptions and Specifications
11.4.5 Hengrui Recent Developments
11.5 JNJ
11.5.1 JNJ Corporation Information
11.5.2 JNJ Overview
11.5.3 JNJ Esketamine Hydrochloride Sales, Price, Revenue and Gross Margin (2017-2022)
11.5.4 JNJ Esketamine Hydrochloride Product Model Numbers, Pictures, Descriptions and Specifications
11.5.5 JNJ Recent Developments
11.6 Pfizer
11.6.1 Pfizer Corporation Information
11.6.2 Pfizer Overview
11.6.3 Pfizer Esketamine Hydrochloride Sales, Price, Revenue and Gross Margin (2017-2022)
11.6.4 Pfizer Esketamine Hydrochloride Product Model Numbers, Pictures, Descriptions and Specifications
11.6.5 Pfizer Recent Developments
12 Industry Chain and Sales Channels Analysis
12.1 Esketamine Hydrochloride Industry Chain Analysis
12.2 Esketamine Hydrochloride Key Raw Materials
12.2.1 Key Raw Materials
12.2.2 Raw Materials Key Suppliers
12.3 Esketamine Hydrochloride Production Mode & Process
12.4 Esketamine Hydrochloride Sales and Marketing
12.4.1 Esketamine Hydrochloride Sales Channels
12.4.2 Esketamine Hydrochloride Distributors
12.5 Esketamine Hydrochloride Customers
13 Market Drivers, Opportunities, Challenges and Risks Factors Analysis
13.1 Esketamine Hydrochloride Industry Trends
13.2 Esketamine Hydrochloride Market Drivers
13.3 Esketamine Hydrochloride Market Challenges
13.4 Esketamine Hydrochloride Market Restraints
14 Key Findings in The Global Esketamine Hydrochloride Study
15 Appendix
15.1 Research Methodology
15.1.1 Methodology/Research Approach
15.1.2 Data Source
15.2 Author Details
15.3 Disclaimer